Toxins from cone snails: properties,applications and biotechnological production |
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Authors: | Stefan Becker Heinrich Terlau |
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Institution: | 1.Department of NMR-based Structural Biology,Max-Planck-Institute for Biophysical Chemistry,G?ttingen,Germany;2.Institute for Experimental and Clinical Pharmacology and Toxicology,Universit?tsklinikum Schleswig-Holstein,Lübeck,Germany |
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Abstract: | Cone snails are marine predators that use venoms to immobilize their prey. The venoms of these mollusks contain a cocktail
of peptides that mainly target different voltage- and ligand-gated ion channels. Typically, conopeptides consist of ten to
30 amino acids but conopeptides with more than 60 amino acids have also been described. Due to their extraordinary pharmacological
properties, conopeptides gained increasing interest in recent years. There are several conopeptides used in clinical trials
and one peptide has received approval for the treatment of pain. Accordingly, there is an increasing need for the production
of these peptides. So far, most individual conopeptides are synthesized using solid phase peptide synthesis. Here, we describe
that at least some of these peptides can be obtained using prokaryotic or eukaryotic expression systems. This opens the possibility
for biotechnological production of also larger amounts of long chain conopeptides for the use of these peptides in research
and medical applications. |
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Keywords: | Conopeptides |
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