A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II |
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| Authors: | M Noda H Suzuki S Numa W Stühmer |
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| Institution: | Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan. |
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| Abstract: | A single point mutation of the rat sodium channel II reduces its sensitivity to tetrodotoxin and saxitoxin by more than three orders of magnitude. The mutation replaces glutamic acid 387 with a glutamine and has only slight effects on the macroscopic current properties, as measured under voltage-clamp in Xenopus oocytes injected with the corresponding cDNA-derived mRNA. |
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