Ribonucleoprotein remodeling during RNA localization |
| |
Authors: | Lewis Raymond A Mowry Kimberly L |
| |
Institution: | Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA. |
| |
Abstract: | Cytoplasmic RNA localization is a means to create polarity by restricting protein expression to a discrete subcellular location. RNA localization is a multistep process that begins with the recognition of cis-acting sequences within the RNA by specific trans-factors, and RNAs are localized in ribonucleoprotein (RNP) complexes that contain both the RNA and numerous protein components. Components of the localization machinery transport the RNP complex, usually in a translationally repressed state, to a distinct subcellular region, resulting in spatially restricted gene expression. Recent efforts to identify both the cis- and trans-factors required for RNA localization have elucidated RNA-protein interactions that are remodeled during localization. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|