Induction of the traits of the differentiated T-cell phenotype in the blast cells of patients with acute lymphoblastic leukemia. I. The expression of T-cell markers as affected by different inducers

The expression of T-lymphocyte markers has been demonstrated by blast cells of patients with non-T, non-B and pre-T-cell acute lymphoblastic leukaemia (ALL). The main inducing agent is phytohemagglutinin (PHA). Its action was enhanced when combined with phorbol ether (TPA) or ouabain. Dimethylsulfoxide, ouabain and concanavalin A had no similar inducing effect. TPA caused the expression of some T-cell markers revealed by monoclonal antibodies but had only a little inducing effect to E-receptor.