Neuroleptic-induced oral movements in rats: methodological issues |
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| Authors: | A D Levy R E See E D Levin G D Ellison |
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| Affiliation: | 1. School of Architecture and Civil Engineering, Xiamen University, 361005, China;2. CONSTRUCT - LESE, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200 465 Porto, Portugal;3. School of Civil Engineering, Central South University, 410075, China;4. National Engineering Laboratory for High-speed Railway Construction, 410075, China;5. Institute of Railway Research, University of Huddersfield, UK;6. IDMEC, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal and ISEL, IPL, Portugal;1. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA;2. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA;1. Assistant Professor and Assistant Attending in Oral & Maxillofacial Pathology, Columbia University College of Dental Medicine;2. Student Researcher, Columbia University College of Dental Medicine;3. Resident, Division of Oral and Maxillofacial Pathology, Columbia University College of Dental Medicine;4. Associate Professor/Attending Pathologist, Division of Oral and Maxillofacial Pathology, Columbia University College of Dental Medicine;5. Assistant Professor/Attending Surgeon, Department of Oral and Maxillofacial Surgery, Columbia University College of Dental Medicine |
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| Abstract: | In three separate experiments groups of rats were chronically administered neuroleptics in a variety of ways (chronic injections, subcutaneous implants, and decanoate injections) and examined for oral movements (OMs) in two different tests: in an open cage using a human observer, or in a plexiglas tube enclosure, where OMs were monitored both by a human observer and computerized video analysis system. These two testing methods showed different effects of neuroleptic administration. In the open cage, OMs tended to be enhanced during chronic neuroleptic exposure and to rapidly subside upon drug withdrawal. The enhanced OMs were especially present just after drug injections, when activity levels were low. In the observation tube environment, however, OMs tended to be low soon after drug treatments, and elevated upon withdrawal. Thus, the type of behavioral test used determines how neuroleptic-induced increases in oral activity should be interpreted. |
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