Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance |
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| Authors: | Kosuke Sakitani Toshihiro Nishizawa Masahide Arita Shuntaro Yoshida Yosuke Kataoka Daisuke Ohki Hiroharu Yamashita Yoshihiro Isomura Akira Toyoshima Hidenobu Watanabe Toshiro Iizuka Yutaka Saito Junko Fujisaki Naohisa Yahagi Kazuhiko Koike Osamu Toyoshima |
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| Affiliation: | 1. Department of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan;2. The Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan;3. Department of Gastroenterology, Tokyo Medical Center, National Hospital Organization, Tokyo, Japan;4. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;5. Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;6. Department of Gastroenterology, Kanto Central Hospital, Tokyo, Japan;7. Department of Colorectal Surgery, Japanese Red Cross Medical Center, Tokyo, Japan;8. Department of Pathology, PCL Japan, Tokyo, Japan;9. Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan;10. Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan;11. Department of Gastroenterology, Cancer Institute Hospital, Tokyo, Japan;12. Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan |
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| Abstract: | Background Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. Materials and Methods All‐cause death rates and gastric cancer‐specific death rates in gastric cancer patients who received successful H. pylori eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy. Results In total, 160 gastric cancer patients were followed‐up for up to 11.7 years (mean 3.5 years). Among them, 53 gastric cancer patients received successful H. pylori eradication therapy prior to gastric cancer diagnosis. During the follow‐up period, 11 all‐cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2 years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan–Meier analysis of all‐cause death and gastric cancer‐specific death revealed a lower death rate in patients in the successful eradication group (P = .0139, and P = .0396, respectively, log‐rank test). The multivariate analysis showed that endoscopy within 2 years before cancer diagnosis is associated with stage I cancer. Conclusions Possible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer. |
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| Keywords: | endoscopic surveillance gastric cancer H. pylori eradication mortality rate |
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