The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin |
| |
Authors: | D M Robertson R Klein F L de Vos R I McLachlan R E Wettenhall M T Hearn H G Burger D M de Kretser |
| |
Institution: | Dept. of Anatomy, Monash University, Melbourne, Australia. |
| |
Abstract: | Three proteins (31, 35 and 39 kDa) with inhibin-like activity have been isolated from bovine follicular fluid with identical NH2-terminal amino acid sequences. These polypeptides are distinct from inhibin, based on their different NH2-amino acid sequence, molecular masses, absence of a subunit structure, absence of inhibin immunoactivity and the failure of inhibin antiserum to neutralize their bioactivity in vitro. Their inhibin-like biological activities based on their ability to suppress FSH cell content by pituitary cells in culture are 5-10% of bovine 31 kDa inhibin. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|