Development of HBsAg-Binding Aptamers that bind HepG2.2.15 cells via HBV surface antigen |
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| Authors: | Jia LIU Yan YANG Bin HU Zhi-yong MA Hong-ping HUANG Yuan YU Shen-pei LIU Meng-ji LU Dong-liang YANG ( |
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| Affiliation: | Jia LIU 1,Yan YANG 2**,Bin HU 1,Zhi-yong MA 1,Hong-ping HUANG 2,Yuan YU 2,Shen-pei LIU 2,Meng-ji LU 3,4 , Dong-liang YANG 1,2 (1.Division of Clinical Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030,China,2.Experimental Medicine Center,3.Department of Microbiology,Wuh... |
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| Abstract: | Hepatitis B virus surface antigen(HBsAg),a specific antigen on the membrane of Hepatitis B virus (HBV)-infected cells,provides a perfect target for therapeutic drugs.The development of reagents with high affinity and specificity to the HBsAg is of great significance to the early-stage diagnosis and treatment of HBV infection.Herein,we report the selection of RNA aptamers that can specifically bind to HBsAg protein and HBsAg-positive hepatocytes.One high affinity aptamer,HBs-A22,was isolated from an initial ... |
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| Keywords: | Aptamer Systematic evolution of ligands by exponential enrichment(SELEX) Hepatitis B virus (HBV) HBsAg Hepatocytes |
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