Assignment of the Y4Receptor Gene (PPYR1) to Human Chromosome 10q11.2 and Mouse Chromosome 14 |
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| Authors: | Karen Darby Helen J Eyre N Lapsys Neal G Copeland Debra J Gilbert Michelle Couzens Olga Antonova Grant R Sutherland Nancy A Jenkins Herbert Herzog |
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| Institution: | aGarvan Institute of Medical Research, Neurobiology Program, St. Vincent's Hospital, Darlinghurst, Sydney, New South Wales, 2010, Australia;bCentre for Medical Genetics, Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, Adelaide, South Australia, 5006, Australia;cMammalian Genetics Laboratory, ABL-Basic Research Program, Frederick Cancer Research and Development Centre, Frederick, Maryland, 21702-1201 |
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| Abstract: | The human and mouse genes for the neuropeptide Y4receptor have been isolated, sequenced, and shown to contain no introns within the coding region of the gene. Nonisotopicin situhybridization and interspecific mouse backcross mapping have localized the genes to human chromosome 10q11.2 and mouse chromosome 14. Five nucleotide variants, which do not alter the protein sequence, have been identified within the coding region of the human receptor gene. The human Y4subtype is most closely related to the Y1-receptor subtype (42%), suggesting that it evolved from an ancestral Y1-like receptor via an RNA-mediated transpositional event. |
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