Reln,an Allele ofReelerIsolated from a Chlorambucil Screen, Is Due to an IAP Insertion with Exon Skipping |
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| Authors: | I. Royaux B. Bernier J.C. Montgomery L. Flaherty A.M. Goffinet |
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| Affiliation: | aDepartment of Physiology, FUNDP Medical School, 61, rue de Bruxelles, B-5000, Namur, Belgium;bMolecular Genetics Program, Wadsworth Center, Albany, New York, 12201-2002 |
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| Abstract: | Thereeler Albany2mutation (Relnrl-Alb2) in the mouse is an allele ofreelerisolated during a chlorambucil mutagenesis screen. Homozygous animals had drastically reduced concentrations ofreelinmRNA, in which an 85-nt exon was absent. At the genomic level, the mutation was shown to be due to an intracisternal A-particle insertion leading to exon skipping. This appears to be the first observation of retrotransposon insertion during chlorambucil mutagenesis. |
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