Deciphering tumor-suppressor signaling in flies: genetic link between Scribble/Dlg/Lgl and the Hippo pathways |
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Authors: | Enomoto Masato Igaki Tatsushi |
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Institution: | 1. Department of Cell Biology, G-COE, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan 2. Department of Cell Biology, G-COE, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan;Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan |
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Abstract: | Loss of apico-basal polarity is one of the crucial factors that drives epithelial tumor progression.scribble/discs large/lethal giant larvae (scrib/dlg/lgl),a group of apico-basal polarity genes,were initially identified as members of “neoplastic” tumor-suppressors in flies.The components of the Hippo signaling pathway,which is crucial for organ size control and cancer development,were also identified through Drosophila genetic screens as members of “hyperplastic” tumor-suppressors.Accumulating evidence in recent studies implies that these two tumor-suppressor signaling pathways are not mutually exclusive but rather cooperatively act to give rise to highly malignant tumors.The interaction of these tumor-suppressor pathways could include deregulations of actin cytoskeleton,cell-cell contact,and apical-domain size of the epithelial cell. |
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Keywords: | Cell polarity Hippo pathway Drosophila scribble dlg lgl Tumor-suppressor Tumor progression |
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