| 绵羊多胎主效基因研究进展 |
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| 作者姓名： | Wang JQ Cao WG |
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| 作者单位： | 中国农业科学院北京畜牧兽医研究所,北京,100193 |
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| 摘 要： | 绵羊存在影响多胎性状的主效基因。BMPR-IB的突变体FecB对排卵数的增加具有增强效应,GDF-9的突变体FecGH和FecI及BMP-15的突变体FecXI、FecXH、FecXG、FecXB、FecXL和FecXR均为纯合子不育,杂合子增加排卵数,而GDF-9的突变体FecGE只有纯合子增加排卵数。Woodlands和Lacaune是遗传方式已知的多胎主效基因。Woodlands是与X染色体连锁的母系印迹基因,Lacaune与FecB类似对排卵数的增加具有增强效应。主效基因突变体单拷贝增加排卵数的效应具有差异性,FecB和FecXL的效应最高可增加1.5个,Woodlands最低可增加0.4个。研究绵羊多胎性状主效基因不仅有助于家畜的选种选育,提高绵羊繁殖力,而且为研究哺乳动物的繁殖机制开拓了新的方向。文章综述了绵羊多胎主效基因的来源、定位、表型、作用机制以及我国绵羊品种多胎主效基因的研究现状,旨在为深入研究绵羊多胎主效基因的作用机制及为绵羊多胎品种的选育提供参考。
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| 关 键 词： | 绵羊 多胎 主效基因 突变体 |
Progress in exploring genes for high fertility in ewes |
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| Wang JQ,Cao WG.Progress in exploring genes for high fertility in ewes[J].Hereditas,2011,33(9):953-961. |
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| Authors: | Wang Jian-Qi Cao Wen-Guang |
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| Institution: | WANG Jian-Qi,CAO Wen-Guang Institute of Animal Sciences and Veterinary Medicine,Chinese Academy of Agricultural Sciences,Beijing 100193,China |
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| Abstract: | Fecundity trait in sheep is regulated by some major genes.Among them,BMPR-IB,BMP-15,and GDF-9 are most distinguishing.The mutant FecB of BMPR-IB has multiplicative effects on ovulation.GDF-9's mutants FecGH,FecI,and BMP-15's mutants FecXI,FecXH,FecXG,FecXB,FecXL,and FecXR increase ovulation rate in the heterozygote but result in sterile phenotypes in the homozygote,while GDF-9's mutant,FecGE,only increases ovulation rate in the homozygote.In addition,Woodlands and Lacaune are known as inheritable major gene... |
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| Keywords: | sheep prolific major gene mutant |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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