神经发育中的细胞周期时程

哺乳动物的神经发育经历一系列神经前体细胞的形态结构和机能改变,其细胞周期时程也呈现动态变化,从神经发生早期至后期,神经前体细胞的细胞周期时程逐渐延长,并与细胞发育命运转归有关,其调节因素包括周期蛋白复合体、Notch信号通路、原神经基因靶向蛋白、微管与分子马达蛋白等。细胞周期长度假说认为,细胞周期的长度影响到命运决定子的积累,因而决定细胞的命运。文章综述了相关的研究进展。

Length of cell cycle in neural development

Neural development of mammals generates a series of morphological and functional alterations in neural precursors.The precursors change the length of cell cycle in the process.Importantly,the changes are related to cell fate determination.Cellular and environmental factors have been elucidated including cyclin complex,notch signal pathway,proneural gene target proteins,microtubule and motor proteins.In the cell-cycle length hypothesis,cell cycle length could influence the accumulation of cell fate determina...