| 果蝇早老素基因的研究进展 |
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| 作者姓名： | Zhang Y Zheng ZZ Ge J Zhang HY Huang YW Song HS |
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| 作者单位： | 上海大学生命科学学院,上海,200444 |
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| 基金项目： | 上海市教委科研创新项目(编号:09YZ38); 上海市科委重点基础项目(编号:10JC1416202); 上海市教育委员会重点学科(第五期)建设项目(编号:J50108)资助 |
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| 摘 要： | 果蝇早老素(Drosophila presenilin,DPS)是一种具有天冬氨酸水解酶活性的蛋白,在果蝇生长发育的各阶段都有表达,对果蝇的生长发育和调节胞内Ca2+平衡具有重要的作用。果蝇早老素功能的缺失能够导致Notch信号下降、神经元凋亡和胞质钙浓度上升,最终造成果蝇长时程记忆损伤和认识丧失。果蝇早老素的这些功能使之成为研究果蝇阿尔茨海默病(Alzheimer’s disease,AD)模型最重要的着手点之一,为阐明AD的病理提供了大量有价值的信息。文章概述了DPS基因与AD相关的功能。
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| 关 键 词： | 果蝇 早老素 阿尔茨海默病 Notch Ca2+ |
Advances on Drosophila presenilin gene |
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| Zhang Y,Zheng ZZ,Ge J,Zhang HY,Huang YW,Song HS.Advances on Drosophila presenilin gene[J].Hereditas,2011,33(11):1164-1170. |
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| Authors: | Zhang Yu Zheng Zeng-Zhang Ge Jun Zhang Hong-Yan Huang Yan-Wang Song Hong-Sheng |
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| Institution: | ZHANG Yu,ZHENG Zeng-Zhang,GE Jun,ZHANG Hong-Yan,HUANG Yan-Wang,SONG Hong-Sheng College of Life Sciences,Shanghai University,Shanghai 200444,China |
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| Abstract: | In Drosophila, presenilin is an aspartyl protease that plays important roles in the development and calcium homeostasis. It has been expressed all through the fly developmental process. The loss of Drosophila presenilin (DPS) function causes significantly decreased Notch signaling and neuron apoptosis and increased cytoplasm calcium. This subsequently led to impaired long term memory and cognitive deficits. Therefore, study of DPS is one of the most popular models for Alzheimer's disease research, and has provided important insights into the pathological mechanisms of AD. This review is to summarize the AD related function of DPS gene. |
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