Privileged structure-based quinazolinone natural product-templated libraries: identification of novel tubulin polymerization inhibitors |
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| Authors: | Liu Ji-Feng Wilson Christopher J Ye Ping Sprague Kevin Sargent Katie Si Ying Beletsky Galina Yohannes Daniel Ng Shi-Chung |
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| Institution: | ArQule, Inc., 19 Presidential Way, Woburn, MA 01801, USA. jliu@arqule.com |
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| Abstract: | A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure. |
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