The long and the short of Wnt signaling in C. elegans |
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Authors: | Hardin Jeff King Ryan S |
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Affiliation: | Graduate Program in Cellular and Molecular Biology, Department of Zoology, University of Wisconsin, 1117 W. Johnson Street, Madison, WI 53706, USA. jdhardin@wisc.edu |
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Abstract: | The simplicity of C. elegans makes it an outstanding system to study the role of Wnt signaling in development. Many asymmetric cell divisions in C. elegans require the Wnt/beta-catenin asymmetry pathway. Recent studies confirm that SYS-1 is a structurally and functionally divergent beta-catenin, and implicate lipids and retrograde trafficking in maintenance of WRM-1/beta-catenin asymmetry. Wnts also regulate short-range events such as spindle rotation and gastrulation, and a PCP-like pathway regulates asymmetric divisions. Long-range, cell non-autonomous Wnt signals regulate vulval induction. Both short-range and long-range Wnt signal s are regulated by recycling of MIG-14/Wntless via the retromer complex. These studies indicate that C. elegans continues to be useful for identifying new, conserved mechanisms underlying Wnt signaling in metazoans. |
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