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H NMR Study of the solution structure of sarafotoxin-S6b |
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| Authors: | Andre Aumelas Laurent Chiche Eve Mahe and Dung Le-Nguyen Philippe Sizun Patrick Berthault and Bruno Perly |
| Institution: | Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France Centre d'Etudes Nucléaires de Saclay, Service de Chimie Moléculaire, Gif sur Yvette, France |
| Abstract: | Sarafotoxin-S6b has been synthesized and studied by 1H NMR in 50/50 acetonitrile/water mixture. All spin systems were identified and assigned with the aid of 2D experiments. On the basis of these data, a 3D structure of sarafotoxin is proposed and compared to that of Nle7]endothelin obtained in the same conditions. From this study, it appeared that sarafotoxin-S6b and Nle7]endothelin roughly share the same 3D structure, the main differences being located in the 4–7 loop bearing the sequence variation. |
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