The interaction between L1-type proteins and ankyrins - a master switch for L1-type CAM function |
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| Authors: | Michael Hortsch Kakanahalli Nagaraj Tanja A Godenschwege |
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| Institution: | (1) Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA;(2) Present address: Department of Applied Zoology, Kuvempu University, Shankaraghatta, Shimoga, India;(3) Department of Biological Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA |
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| Abstract: | L1-type cell adhesion molecules (CAMs) are important mediators of neural differentiation, including axonal outgrowth and pathfinding
and also of synapse formation and maintenance. In addition, their interactions with cytoskeletal components are highly conserved
and regulated. How these different aspects of CAM functionality relate to each other is not well understood. Based on results
from our and other laboratories we propose that ankyrin-binding to L1-type CAMs provides a master switch. The interaction
with ankyrins directs L1-type adhesive proteins into different functional contexts, either ankyrin-independent functions,
such as neurite outgrowth and axonal pathfinding or into ankyrin-dependent functions, such as L1’s role at axon initial segments
(AIS), paranodal regions, synapses and in dendrites.
The content of this Mini review was first presented in a shortened form at the 12th Mejbaum-Katzenellenbogen Seminar “Membrane
Skeleton. Recent Advances and Future Research Directions”, June 15–18, 2008, Zakopane, Poland |
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| Keywords: | Cell adhesion Ankyrins Membrane skeleton Tyrosine phosphorylation Neurite outgrowth Neuromuscular junction Synapse Synaptogenesis Drosophila |
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