Synthesis and biological evaluation of some novel 4'-thio-L-ribonucleosides with modified nucleobase moieties |
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Authors: | Pejanović Vjera Stokić Zdenka Stojanović Biljana Piperski Vesna Popsavin Mirjana Popsavin Velimir |
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Affiliation: | Galenika AD, Batajnicki drum bb, 11000 Belgrade, Yugoslavia. vpejanovic@hemofarm.co.yu |
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Abstract: | 1,2,3,5-tetra-O-acetyl-4-thio-beta-L-ribofuranose (13) was synthesized by an improved five-step sequence starting from methyl alpha-D-lyxopyranoside. Compound 13 was then converted to the corresponding L-4'-thionucleosides 4-6 and 19 by a modified Vorbrüggen procedure. All of these nucleoside analogues were tested for their antitumour activity in vitro. |
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