Effects of ENU dosage on mouse strains |
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| Authors: | Monica J Justice Don A Carpenter Jack Favor Angelika Neuhauser-Klaus Martin Hrabé de Angelis Dian Soewarto Amy Moser Sabine Cordes Darla Miller Verne Chapman John S Weber Eugene M Rinchik Patricia R Hunsicker William L Russell Vernon C Bode |
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| Institution: | (1) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA, US;(2) Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA, US;(3) GSF-National Research Center for Environment and Health, Neuherberg, Germany, DE;(4) Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA, US;(5) Samuel Lunenfeld Institute, Mount Sinai Hospital, Toronto, Canada, CA;(6) Roswell Park Cancer Institute, Buffalo, New York, USA, US;(7) Division of Biology, Kansas State University, Manhattan, Kansas 66706, USA, US |
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| Abstract: | The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ
in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of
ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number
of laboratories that have exposed male mice from inbred and non-inbred strains or their F1 hybrids to ENU. The results show that most F1 hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover
fertility after treatment with ENU.
Received: 11 February 2000 / Accepted: 11 February 2000 |
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