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Synthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives |
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| Authors: | Desplat Vanessa Moreau Stéphane Belisle-Fabre Solene Thiolat Denis Uranga Juliette Lucas Romain de Moor Laure Massip Stéphane Jarry Christian Mossalayi Djavad M Sonnet Pascal Déléris Gérard Guillon Jean |
| Affiliation: | Université Bordeaux Segalen, CNRS FRE 3396, Pharmacochimie, Bordeaux. |
| Abstract: | A novel series of isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives was synthesized and evaluated in vitro against various human cancer cell lines for antiproliferative activity. These new compounds displayed activity against leukemia and breast cancer cell lines in the 3- to 18-μM concentration range. |
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