| 一氧化氮/内皮素在大鼠胃粘膜损伤中的作用及电针的调整效应 |
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| 引用本文： | Sun Y,Xu GS,Liu WP,Xu NG. 一氧化氮/内皮素在大鼠胃粘膜损伤中的作用及电针的调整效应[J]. 生理学报, 1999, 0(2): 206-210 |
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| 作者姓名： | Sun Y Xu GS Liu WP Xu NG |
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| 作者单位： | 安徽中医学院针灸经络研究所生理研究室,合肥,230038 |
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| 摘 要： | 用酒精灌胃引起大鼠胃粘膜损伤模型,观察内皮衍生因子（ＮＯ／ＥＴ）的含量变化和电针对胃粘膜损伤调整作用,结果发现：酒精灌胃后,胃粘膜血流量（ＧＭＢＦ）、跨壁电位差,血ＮＯ含量降低（Ｐ〈０．０１）,血浆ＥＴ含量和胃粘膜损伤指数（ＬＩ）增高（Ｐ〈０．０１）。Ｌ－精氨酸（Ｌ－Ａｒｇ）或硝普钠（ＳＮＰ）灌注预处理后（ｉｖ）,ＮＯ含量和ＧＭＢＦ明显升高（Ｐ〈０．０１）,ＥＴ含量和ＬＩ指数下降（Ｐ〈０．０１）。
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| 关 键 词： | 胃粘膜损伤 一氧化氮 内皮素 电针 |
The role of NO/ET and the effect of electroacupuncture on injuried gastric mucosa in rats |
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| Sun Y,Xu G S,Liu W P,Xu N G. The role of NO/ET and the effect of electroacupuncture on injuried gastric mucosa in rats[J]. Acta Physiologica Sinica, 1999, 0(2): 206-210 |
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| Authors: | Sun Y Xu G S Liu W P Xu N G |
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| Affiliation: | Physiology Research Laboratory, Institute of Acupuncture and Meridian, AnHui College of Traditional Chinese Medicine, Hefei 230038. |
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| Abstract: | The aim of the present work is to observe changes in endotheliumderived factors nitric oxide(NO)and endothelin(ET), with special reference to the regu.lative role of electroacupuncture(EA)in injured gastric mucosa of rat by ethanol. It was found that gastric mucosal blood flow(GMBF), transmucosal potential difference(PD)and the content of NO in the serum all decreased (P<001), while the content of ET in the plasma and the lesion index(LI) of gastric mucosa increased(P<001). After administration of LArg and SNP, the content of NO and GMBF increased significantly(P<001), whereas the content of ET and LI decreased (P<001). These effects were enhanced by EA at ZuSanLi (ST36) points, which, however, were inhibited by NO biosynthetic inhibitor LNNA. The latter effect could be reversed by concurrent administration of LArg. The above results suggest that NO plays a critical part in protecting gastric mucosa against injury, which is also responsible for the protective effect of EA on injury of gastr |
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| Keywords: | gastric mucosal injury nitric oxide (NO) endothelin (ET) electroacupuncture (EA)ic mucosa. |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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