A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon |
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Authors: | Sanchez David Jesse Miranda Daniel Arumugaswami Vaithilingaraja Hwang Seungmin Singer Adam E Senaati Ashkon Shahangian Arash Song Moon Jung Sun Ren Cheng Genhong |
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Affiliation: | Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. |
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Abstract: | Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon. |
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