NOXclass: prediction of protein-protein interaction types |
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Authors: | Hongbo Zhu Francisco S Domingues Ingolf Sommer Thomas Lengauer |
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Institution: | 1. Max-Planck-lnstitut für Informatik, Stuhlsatzenhausweg 85, 66123, Saarbrücken, Germany
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Abstract: | Background Structural models determined by X-ray crystallography play a central role in understanding protein-protein interactions at
the molecular level. Interpretation of these models requires the distinction between non-specific crystal packing contacts
and biologically relevant interactions. This has been investigated previously and classification approaches have been proposed.
However, less attention has been devoted to distinguishing different types of biological interactions. These interactions
are classified as obligate and non-obligate according to the effect of the complex formation on the stability of the protomers.
So far no automatic classification methods for distinguishing obligate, non-obligate and crystal packing interactions have
been made available. |
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Keywords: | |
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