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CpGcluster: a distance-based algorithm for CpG-island detection |
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| Authors: | Michael Hackenberg Christopher Previti Pedro Luis Luque-Escamilla Pedro Carpena José Martínez-Aroza José L Oliver |
| Institution: | (1) Dpto. de Gentica, Facultad de Ciencias, Universidad de Granada, Granada, Spain;(2) Dpto. de Ingeniera Mecnica y Minera, Universidad de Jan, Jan, Spain;(3) Dpto de Fsica Aplicada II, Universidad de Mlaga, Mlaga, Spain;(4) Dpto. de Matemtica Aplicada, Facultad de Ciencias, Universidad de Granada, Granada, Spain;(5) Dept. of Molecular Biophysics, German Cancer Research Center, Heidelberg, Germany |
| Abstract: | BackgroundDespite their involvement in the regulation of gene expression and their importance as genomic markers for promoter prediction, no objective standard exists for defining CpG islands (CGIs), since all current approaches rely on a large parameter space formed by the thresholds of length, CpG fraction and G+C content. |
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