Comparison of different bioreactor performances |
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| Authors: | Professor Dr. Dr. h. c. K. Schügerl |
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| Affiliation: | (1) Institut für Technische Chemie, Universität Hannover, Callinstr. 3, D-30167 Hannover, FRG |
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| Abstract: | Bioreactors are compared based on oxygen transfer rate and efficiency, mixing performance, cell mass productivity as well as with respect to enzyme and metabolite productivity.List of Symbols AC acetate concentration - AL airlift tower loop reactor - CFU colony-forming units - CP coalescence-promoting medium - CS coalescence-suppressing medium - DD impeller clearance - DM molecular diffusivity - DS diameter of the column - DT flat-bladed disc turbine - Dv vessel diameter - E. act enzyme activity - EDR energy dissipation rate - EcoRI restriction endonuclease - EcoR4 protection plasmid - EO2 efficiency of oxygen transfer rate - EX efficiency of cell mass production with respect to the specific power input - g acceleration of gravity - H height of column - Hv vessel height - HV highly viscous medium - IPTG isopropyl thiogalactoside (inducer of Lacpromoter) - k fluid consistency factor - kL mass transfer coefficient - kLa volumetric mass transfer coefficient - m exponent - N impeller speed - n exponent - n flow behaviour index - P power input - P/VL specific power input - PR marine propeller - PLacUV5 Lac-promoter-induced by IPTG - PR promoter-induced with temperature shift -  O2 oxygen transfer rate - qg,qO2 aeration rate, specific aeration rate with respect to liquid volume - R density of cultivation medium - Rp product formation rate - RX growth rate - SpA protein A - ST stirred tank reactor - TCC total cell count - tLc liquid circulation time - U enzyme activity unit - uB bubble rise velocity - uG superficial gas velocity - VL volume of the liquid phase - v kinematic viscosity of the cultivation medium - WSG superficial gas velocity - X cell mass concentration - YE/S yield coefficient of ethanol formation with respect to substrate consumption - YP/X specific product formation with respect to cell concentration - YX/E yield coefficient of cell growth with respect to ethanol consumption - YX/O2 yield coefficient of cell growth with respect to oxygen consumption rate - YX/S yield coefficient of growth with respect to substrate consumption -  L liquid mixing time -  eff effective dynamic viscosity of the cultivation medium - W dynamic viscosity of water - max maximum specific growth rate -  surface tension of the cultivation medium |
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