Analysis of phenylethylamines in biological tissues by gas-liquid chromatography with electron-capture detection |
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| Authors: | D J Edwards K Blau |
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| Affiliation: | 1. Selcuk University, Science Faculty, Department of Biology, Campıus, Konya, Turkey;2. Department of Pharmacy, University “G. d’Annunzio” Chieti-Pescara, 66100, Chieti, Italy;3. Centre of Marine Sciences, University of Algarve, Faculty of Sciences and Technology, Ed. 7, Campus of Gambelas, 8005-139, Faro, Portugal;4. Department of Health Sciences, Faculty of Science, University of Mauritius, 230, Réduit, Mauritius;1. Green City Technology Institute, Korea Institute of Science and Technolgy, Seoul 136-791, South Korea;2. Department of Chemistry, Dong-A University, Busan 604-714, South Korea;3. Korea Institute of Geoscience and Mineral Resources, 124 Gwahang-no, Daejeon 305-350, South Korea;4. Department of Environmental Engineering, Yonsei University, Wonju 220 710, South Korea;1. Daejeon Institute, National Forensic Service , 1524 Yuseongdaero, Yuseong-gu, Daejeon 34054, Republic of Korea;2. College of Pharmacy, Chungbuk National University, 1 Chungdaero, Seowon-gu, Cheongju, Chungbuk 28356, Republic of Korea;3. Drug & Forensic Toxicology Division, National Forensic Service, 10 Ipchunro, Wonjusi, Gangwondo 26460, Republic of Korea |
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| Abstract: | 2,4-Dinitrophenyl derivatives of phenylethylamines have been applied to the sensitive quantitative analysis of phenylethylamines in biological tissues by gas chromatography and electron-capture detection. The minimal detectable amounts are about 0.1 ng. A rapid and specific cleanup procedure allows the injection of 10% of all the amines extracted from 200 mg tissues, so that as little as 20 ng/gm tissue can be determined. Amines with or without hydroxyl groups can be determined as the DNP-derivatives with equal sensitivity. The corresponding 3,5-dinitro-4-trifluoromethyl derivatives were also prepared and their chromatographic behavior is reported. |
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