(1) Penn Center for Bioinformatics, Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104-6021, USA
Abstract:
Background
The currently used kthorder Markov models estimate the probability of generating a single nucleotide conditional upon the immediately preceding (gap = 0) k units. However, this neither takes into account the joint dependency of multiple neighboring nucleotides, nor does it consider the long range dependency with gap>0.
