Dimethyl titanocene Y: A valuable precursor for libraries of cytotoxic titanocene derivatives |
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Authors: | Timo A Immel |
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Institution: | Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstrasse 10, Fach 720, 78457 Konstanz, Germany |
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Abstract: | Reaction of the known titanocene Y 2 with methyl lithium at −15 °C yields bis-(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dimethyl (dimethyl titanocene Y, 3), a hitherto unknown, surprisingly robust titanium (IV) dimethyl species. Dimethyl titanocene Y was utilized in the preparation of several bis-(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dicarboxylates by the reaction with the free carboxylic acids in fair to good yields. Cytotoxicity of all new compounds has been estimated in Hela S3 cells. |
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Keywords: | Cytotoxicity Titanium complexes Library-synthesis Cancer |
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