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Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes |
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| Authors: | Kusaï Alomar Marie Kempf Magali Allain |
| Institution: | a Laboratoire SONAS, EA 921, IFR QUASAV 149, Université d’Angers, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Boulevard Daviers, 49045 Angers cedex 01, France b Laboratoire de Bactériologie, CHU d’Angers, 4 rue Larrey, 49933 Angers cedex 9, France c Laboratoire de Chimie, Ingénierie Moléculaire d’Angers (CIMA), UMR CNRS 6200 - Université d’Angers, 2, Boulevard Lavoisier, 49045 Angers cedex, France |
| Abstract: | The reaction of zinc(II) chloride, cadmium(II) chloride and bromide with 3-thiophene aldehyde thiosemicarbazone leads to the formation of a series of new complexes. They have been characterized by spectroscopic studies: infrared, 1H NMR, and electronic spectra. The crystal structures of the compound ZnCl2(3TTSCH)2] and CdBr2(3TTSCH)2] have been determined by X-ray diffraction methods. For the complexes ZnCl2(3TTSCH)2] and CdBr2(3TTSCH)2], the central ion is coordinated through the sulfur, and for the complexes CdCl2(3TTSCH)], CdBr2(3TTSCH)] the ion is coordinated through the sulfur as well as azomethine nitrogen atom of the thiosemicarbazone. In addition, fungistatic and bacteriostatic activities of both ligand and complexes have been evaluated. Cadmium(II) complexes have shown the most significant activities. |
| Keywords: | Thiosemicarbazone 3-thiophene aldehyde Crystal structure Metal complexes Biological activity |
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