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Differential effects of Co(III), Ni(II), and Ru(III) amine complexes on Sindbis virus |
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| Authors: | D Andrew Knight Thomas E Hickey Dzung C Thach R Yngard |
| Institution: | a Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375, USA b Department of Chemistry, Loyola University New Orleans, 6363 St. Charles Avenue, New Orleans, LA 70118, USA c Chemistry Department, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901, USA d Nova Research, Inc., 1900 Elkin Street, Suite 230, Alexandria, VA 22308, USA |
| Abstract: | Transition metal complexes Co(cyclen)(NH3)2](ClO4)3⋅H2O (cyclen = 1,4,7,10-tetraazacyclododecane) (2), Co(NH3)5(OH2)](CF3SO3)3 (3) Ni(NH3)6]Br2 (4) and Ru(NH3)6]Cl3 (5) were tested against Sindbis infected baby hamster kidney (BHK) cells and show differential effects from the previously reported anti-viral complex Co(NH3)6]Cl3 (1). The macrocyclic complex 2 and labile aqua complex 3 show either no or little effect on the survival on Sindbis virus-infected cells as compared to that for 1, which show a monotonic increase in % BHK cell survival. Nickel and ruthenium ammine complexes 4 and 5 had a moderate influence of cell survival. While the results showed some anti-viral activity for some of the structural variations, it appears that 1, with its potential to be a broad-spectrum anti-viral compound, occupies a unique position in its ability to both significantly enhance cell survival and to decrease viral expression of infected cells. We also show that 1 also shows anti-viral activity against Adenovirus lending support to the broad-spectrum potential of this complex. |
| Keywords: | Hexaamminecobalt(III) chloride Anti-viral Metal complexes Broad-spectrum drug |
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