A caged nicotine with nanosecond range kinetics and visible light sensitivity |
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| Authors: | Oscar Filevich |
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| Institution: | Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2 Piso 3, C1428EHA, Buenos Aires, Argentina |
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| Abstract: | We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex Ru(bpy)2(nic)2]2+ (where bpy = 2,2′ bipyridine and nic = nicotine (3-(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield ? = 0.23 upon irradiation with biologically harmless, blue (473 nm) or green (532 nm) light. The photolysis reaction is clean and very fast, with a time constant of 17 ns. The synthesis is simple and the obtained compound is characterized by NMR, UV-Vis spectroscopy and cyclic voltametry. We find that this compound is active in biological systems, being able to elicit action potentials in leech neurons. |
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| Keywords: | Caged compound Ruthenium complex Nicotine Leech Neurotransmitter nAChR |
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