The (Ca + Mg)-ATPase of reticulocytes |
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Authors: | B F Cameron L Green |
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Institution: | Cincinnati Comprehensive Sickle Cell Center Children''s Hospital Research Foundation Elland & Bethesda Ave., Cincinnati, Ohio 45229, Canada |
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Abstract: | Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium-dependent calcium-stimulated adenosine triphosphatase ( ( Ca + Mg)-ATPase, EC 3.6.1.3.) of the red cell plasma membrane was not significantly changed. Maximal activity in the presence of calmodulin was significantly reduced, the stimulation by the activator falling from about 350% to about 50%. |
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