Cloning of a polymorphic canine genetic marker which maps to human chromosome 9 |
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| Authors: | B. Hershfield G. Chader G. Aguirre B. Hershfield G. Aguirre G. Chader |
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| Affiliation: | Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, Cornell University, Ithaca, New York 14853, USA;Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA |
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| Abstract: | We describe the cloning of a novel canine polymorphic genetic marker which maps to human chromosome 9. The sequence is 2092 bp, 59% GC rich, and contains three GC boxes. Chemilumin-escent probing of zooblots showed evolutionary conservation. Dogs have three Bam HI alleles: 2.3 kb, 2.1 kb and 1.7 kb. Allele frequencies in 17 unrelated dogs representing 13 breeds are presented. Polymorphism for the 1.7-kb allele in beagles is common. The 2.1-kb allele is probably the ancestral allele since it is the most common and is also noted in the Cape hunting dog. Interestingly, in more than 50 dogs tested to date, the 2.3-kb allele has been found only in miniature and giant schnauzers. This points to a common origin for these two breeds. |
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| Keywords: | dog genetics chromosomal evolution polymorphism |
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