Effect of chronic administration of doxorubicin on cardiac adenylate cyclase activity in mice |
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| Authors: | T W Robison S N Giri |
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| Institution: | 1. Tecnologico de Monterrey, School of Engineering and Sciences Av. Carlos Lazo No. 100, Álvaro Obregón, Ciudad de México, 01389, México;2. Tecnologico de Monterrey, School of Engineering and Sciences Av. Eugenio Garza Sada 2501 Sur, Monterrey, N.L., 64849, México;3. Tecnologico de Monterrey, School of Engineering and Sciences Carretera al Lago de Guadalupe Km. 3.5, Atizapán de Zaragoza, Estado de México, C.P. 52926, México;4. Tecnologico de Monterrey, School of Engineering and Sciences Vía Atlixcáyotl No. 2301, Reserva Territorial Atlixcáyotl, Puebla, 72453, México;5. Tecnologico de Monterrey, School of Engineering and Sciences Av. General Ramón Corona No. 2514, Zapopan, Jalisco, 45138, México;1. Medical Faculty of Muhammadiyah University, Makassar, Indonesia;2. Department of Orthopaedic and Traumatology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia;3. Medical Faculty of Bosowa University, Makassar, Indonesia;1. Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom;2. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden;3. Latin American Brain Health Institute (BrainLat) & Center for Social and Cognitive Neuroscience, Universidad Adolfo Ibáñez, Santiago, Chile;4. Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina;5. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina;6. Global Brain Health Institute, University of California San Francisco, San Francisco, United States of America, and Trinity College Dublin, Dublin, Ireland;7. Department of Psychology, University of Cambridge, Cambridge, United Kingdom;8. Vicerrectoría de Investigación y Posgrado, Universidad Católica del Maule, Talca, Chile;1. Faculty of Economics and Business, KU Leuven, Belgium;2. Flanders Business School, Antwerp, Belgium |
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| Abstract: | Cardiac adenylate cyclase activity was examined in mice treated chronically with doxorubicin. Mice received a subcutaneous dose of either 2 or 4 mg/kg doxorubicin twice weekly for 5 weeks. Mice were sacrificed five weeks after the last injection. Basal cardiac adenylate cyclase activity was significantly elevated in both the 2 and 4 mg/kg DXR-treated groups over the control level. GTP, isoproterenol (plus GTP), NaF, and forskolin stimulated activities in both the 2 and 4 mg/kg DXR-treated groups were also significantly elevated over control levels. |
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