Synthesis and metabolism of prostaglandins E2, F2α and D2 by the rat gastrointestinal tract. Stimulation by a hypertonic environment in vitro |
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Authors: | Howard R Knapp Oswald Oelz Brian J Sweetman John A Oates |
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Institution: | Departments of Pharmacology and Medicine Vanderbilt University School of Medicine Nashville, Tennessee 37232, USA |
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Abstract: | Whole cell preparations of rat stomach corpus, jejunum, and colon were incubated and the released prostaglandin E2 (PGE2), PGF2α, PGD2, 15 keto-13,14 dihydro PGE2, and 15 keto-13,14 dihydro PGF2α were measured by combined gas chromatography-mass spectrometry. All regions made PGD2 and possessed a high capacity for producing 15 keto-13,14 dihydro derivatives of both PGE2 and PGF2α. Hypertonic sucrose solutions resulted in concentration-dependent increases in prostaglandin release, particularly of PGE2 and its metabolite. It is suggested that PG's may play a role in the local effects of luminal hyperosomolarity on digestive tract functions. |
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