Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network |
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Authors: | E. Leonardi A. Murgia |
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Affiliation: | a Department of Biology, University of Padua, 35131 Padua, Italy b Department of Pediatrics, University of Padua, 35131 Padua, Italy |
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Abstract: | The von Hippel-Lindau (VHL) tumor suppressor gene is a protein interaction hub, controlling numerous genes implicated in tumor progression. Here we focus on structural aspects of protein interactions for a list of 35 experimentally verified protein VHL (pVHL) interactors. Using structural information and computational analysis we have located three distinct interaction interfaces (A, B, and C). Interface B is the most versatile, recognizing a refined linear motif present in 17 otherwise non-related proteins. It has been possible to distinguish compatible and exclusive interactions by relating pVHL function to interaction interfaces and subcellular localization. A novel hypothesis is presented regarding the possible function of the N-terminus as an inhibitor of pVHL function. |
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Keywords: | Von Hippel-Lindau Hypoxia inducible factor Structural bioinformatics Linear motif Protein interaction |
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