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Helicobacter pylori and gastric autoimmunity |
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| Authors: | Mario Milco D&#x;Elios Mathijs P Bergman Amedeo Amedei Ben J Appelmelk Gianfranco Del Prete |
| Institution: | aDepartment of Internal Medicine, University of Florence, Viale Morgagni, 85-50134 Florence, Italy;bDepartment of Medical Microbiology, Vrije Universiteit, Medical School, van der Boechorstraat 7, 1081 BT Amsterdam, The Netherlands;cDepartment of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands |
| Abstract: | Host specific T-cell response is critical for the outcome of Helicobacter pylori infection. In genetically susceptible individuals, H. pylori can activate gastric CD4+ Th1 cells that recognize cross-reactive epitopes shared by H. pylori proteins and self H+, K+-ATPase, leading to gastric autoimmunity via molecular mimicry. |
| Keywords: | Autoimmunity Mimicry Mucosal immunity Th1– Th2 response Cytokines Helicobacter pylori Atrophic gastritis Apoptosis H+ K+-ATPase |
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