Undetectable levels of tumor necrosis factor-alpha,nitric oxide and inadequate expression of inducible nitric oxide synthase in congenital hypothyroidism |
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Authors: | Rodríguez-Arnao M D Rodríguez-Sánchez A Rodríguez-Arnao J Dulín- Iñiguez E Cano J M Bellón Muñoz-Fernández M A |
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Affiliation: | Hospital General Universitario Gregorio Mara?ón, Servicio de Inmunología, C/Dr Esquerdo 46, 28007 Madrid, Spain. |
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Abstract: | OBJECTIVE: To analyse the production of TNF-alpha and NO in euthyroid and hypothyroid newborns. PATIENTS: A cross-sectional study was conducted involving 10 newborns diagnosed with primary congenital hypothyroidism (CH; group A) and 10 euthyroid children (group B). RESULTS: There were undetectable plasma levels of TNF-alpha and NO in the hypothyroid children, however plasma levels of TNF-alpha (5.5 0.5 pg/ml) and NO (5.6 1.7 microM) were detected at normal levels in all euthyroid children. Moreover, expression of iNOS mRNA in PBMC, determined by RT-PCR, was negative in both groups of infants. CONCLUSION: TNF-alpha and NO production are both impaired in hypothyroid newborns. We report for the first time evidence of undetectable levels of TNF-alpha and NO in infants with CH. |
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