New constituents from the dried fruit of Piper nigrum Linn., and their larvicidal potential against the Dengue vector mosquito Aedes aegypti |
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| Authors: | Tahsin Gulzar Nizam Uddin Bina Shaheen Siddiqui Syed N.H. Naqvi Sabira Begum Rajput Muhammed Tariq |
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| Affiliation: | 1. Department of Applied Chemistry, G. C. University, Allama Iqbal Road, Faisalabad, Pakistan;2. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan;3. Center of Excellence in Marine Biology, University of Karachi, Karachi-75270, Pakistan;4. Department of Pharmacology, Baqai Medical University, Karachi, Karachi-74600, Pakistan;5. MAHQ, Biological Research Center, University of Karachi, Pakistan |
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| Abstract: | Six bioactive compounds were isolated from the seeds extract of Piper nigrum Linn. following a larvicidal activity guided isolation against 4th instar larvae of Aedes aegypti L., a Dengue vector mosquito and a carrier of yellow fever. Their structures were elucidated using spectroscopic methods including HR-EI-MS, FAB-MS, 1H and 13C NMR (Broad Bond Decoupled, & DEPT), and 2D-NMR techniques (1H–1H COSY, NOESY, HMQC, HMBC, & 2D-J-resolved). These include three new constituents namely pipilyasine (1), pipzubedine (2) and pipyaqubine (3), and three known constituents pellitorine (4), pipericine (5) and piperine (6). The larvicidal activity was determined by WHO method. |
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