Austdiol,fulvic acid and citromycetin derivatives from an endolichenic fungus,Myxotrichum sp. |
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| Authors: | Chao Yuan Hai-Ying Wang Chang-Sheng Wu Yang Jiao Ming Li Yan-Yan Wang Shu-Qi Wang Zun-Tian Zhao Hong-Xiang Lou |
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| Institution: | 1. Institute of Medicinal Plant Development Yunnan Branch, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, People''s Republic of China;2. Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, People''s Republic of China;3. College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Jinan 250014, People''s Republic of China |
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| Abstract: | A new austdiol analog myxodiol A (1), three novel fulvic acid derivatives myxotrichin A–C (2–4), and a new citromycetin analog myxotrichin D (5), were isolated from an endolichenic fungus Myxotrichum sp. inhabiting the lichen Cetraria islandica (L.) Ach. The structures of these compounds were elucidated unequivocally on the basis of comprehensive analysis of MS and NMR data. Compounds 2 and 5 displayed very weak cytotoxicity against human leukemia cell line K562, and compounds 1 showed very weak antifungal activity against Candida albicans (sc5314). |
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| Keywords: | Endolichenic fungus Metabolites Antigungal activity Cytotoxicity |
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