Antiplasmodial and cytotoxic activities of Striga asiatica and Sauropus spatulifolius extracts,and their isolated constituents |
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| Authors: | Ying-Shu Zou Kenn Foubert Emmy Tuenter Filip Lemière Paul Cos Louis Maes Jan M.M. Smits René de Gelder Sandra Apers Luc Pieters |
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| Affiliation: | 1. Natural Products & Food – Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Belgium;2. Biomolecular Mass Spectrometry, Centre for Proteome Analysis and Mass Spectrometry (CeProMa), University of Antwerp, Belgium;3. Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Belgium;4. Radboud University Nijmegen, Solid State Chemistry, Institute for Molecules and Materials, The Netherlands |
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| Abstract: | A phytochemical investigation of Striga asiatica and the leaves of Sauropus spatulifolius revealed seventeen compounds, three of which were reported for the first time from nature, i.e. two alkaloids N-hydroxyethyl-2-acetylpyrrole, N-(3-carboxypropyl)-2-acetylpyrrole, and 2-(4-hydroxy-2,2,6-trimethylcyclohexyl)acetic acid, for which the name sauropic acid was adopted. Their structures were established spectroscopically and by single-crystal X-ray diffraction analysis. All extracts and isolates were evaluated for antiplasmodial activity against Plasmodium falciparum strain K1 and for cytotoxicity against MRC-5 cells. |
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