Eudesmane sesquiterpenoid lactones and abietane diterpenoids from Ajuga forrestii Diels |
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| Authors: | Yan Xiong Wei Qu Jian-bo Sun Meng-hua Wang Jing-yu Liang |
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| Institution: | 1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China;2. Nanjing Lifenergy R&D Co., Ltd., Nanjing 210016, PR China |
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| Abstract: | Four eudesmane sesquiterpenoid lactones (1–4) and seven abietane diterpenoids (5–11) were isolated from the whole plants of Ajuga forrestii. Among them, 3α-acetoxy-1α,8β-dihydroxyeudesm-7(11)-en-8,12-olide (1), 3α-acetoxy-1α-hydroxyl-eudesm-8,7(11)-dien-8,12-olide (2), 1α-acetoxy-8α-oxyethyl-2-oxo-eudesman-3,7(11)-dien-8,12-olide (3) and 2α,3β,11,12-tetrahydroxy-7β,20-epoxy-8,11,13-abietatriene (11) are novel compounds. The structures of compounds 1–11 were determined by spectroscopic analysis. Compound 2 exhibited weak cytotoxicity on HepG2 and MCF-7 cell lines. |
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| Keywords: | Sesquiterpenoid lactones Diterpenoids Cytotoxicity |
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