Polyisoprenylated benzophenone and xanthone constituents of the bark of Garcinia cochinchinensis

A new polyisoprenylated benzophenone, guttiferone T, three other benzophenones, (?)-30-epi-cambogin, (?)-guttiferone G and (?)-garcinialiptone A, together with six xanthones, tovophyllin B, nigrolineaxanthone V, pedunxanthone A, tovophyllin A, parvifolixanthone B and dulxanthone A, were isolated from the bark of Garcinia cochinchinensis. Their structures were elucidated using spectroscopic methods, mainly 1-D and 2-D NMR. Three of the polyisoprenylated benzophenone were tested for their cytotoxicity towards two human cancer cell lines, Hela and MCF-7, and exhibited weak activity.