Triterpenoid saponins from Sesbania vesicaria |
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Authors: | Wei Yuan Ping Wang Zhizhen Zhang Zushang Su Shiyou Li |
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Institution: | National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75972-6109, USA |
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Abstract: | Nine oleanane saponins including three new and six known were isolated from the seeds of Sesbania vesicaria. The new saponins were established as 3-O-α-l-rhamnopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl-3β,29-dihydroxy-olean-12-en-28-oic acid, 3-O-α-l-rhamnopyranosyl-28-O-β-d-glucopyransoyl-3β-hydroxy-olean-12-en-23-al-28-oate, and 3-O-α-l-rhamnopyranosyl-28-O-β-d-glucopyransoyl-3β,23-dihydroxy-olean-12-en-28-oate. All isolated saponins were assayed for their DNA topoisomerase I inhibition ability and cytotoxicity against A549 human lung adenocarcinoma epithelial cells with no positive activity detected (IC50 > 312 μM and GI50 > 25 μM, respectively). |
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