Novel inhibitors of urease from Corydalis govaniana Wall. |
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| Authors: | R.L. Shrestha Achyut Adhikari Bishnu P. Marasini R.N. Jha M. Iqbal Choudhary |
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| Affiliation: | 1. Department of Chemistry, Tri-Chandra Campus, Tribhuvan University, Kathmandu, Nepal;2. Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu, Nepal;3. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan;4. Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21412, Saudi Arabia |
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| Abstract: | A new compound govaniadine (1), along with three known tetrahydroprotoberberine-type alkaloids caseadine (2), caseamine (3), and protopine (4), were isolated from the plant Corydalis govaniana Wall. All alkaloids 1–4 exhibited a good urease enzyme inhibition with IC50 ± S.E.M. values of 20.2 ± 3.6, 38.9 ± 2.8, 66.7 ± 1.2, and 54.1 ± 1.2 μM, respectively, which are comparable to the standard inhibitor, acetohydroxamic acid (IC50 = 42.0 μM). None of these compounds showed inhibition against α-chymotrypsin. This is the first report of urease inhibiting tetrahydroprotoberberine-type alkaloids. |
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