Two new rocaglamide derivatives from twigs of Aglaia odorata var. microphyllina |
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| Authors: | Shuai Liu Hui Wang Wen-jian Zuo You-xing Zhao Xiao-na Li Wen-li Mei Hao-fu Dai |
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| Institution: | 1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China;2. Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, PR China;3. Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources, Ministry of Education/Horticultural and Garden College, Hainan University, Haikou 570228, PR China |
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| Abstract: | Phytochemical investigation of Aglaia odorata var. microphyllina led to the isolation of two new rocaglamide derivatives and three known ones. The structures of the two new compounds were elucidated as 8b-methoxy-desmethylrocaglamide (1) and 3′-hydroxy-8b-methoxy-rocaglamide (2) by spectroscopic techniques (IR, MS, 1D and 2D NMR) and comparing with published data. All the five compounds were evaluated for cytotoxic activity against K562 cell line by MTT method. The results indicated that the OH at 8b position was a decisive group for cytotoxic activity. |
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