Three new flavonoids from the leaves of oriental tobacco and their cytotoxicity |
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| Authors: | Jinxiong Chen Hongqiong Leng Yuanxing Duan Wei Zhao Guangyu Yang Yadong Guo Yongkuan Chen Qiufen Hu |
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| Institution: | 1. Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, PR China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China;3. School of Pharmacy, Kunming Medical University, Kunming 650500, PR China |
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| Abstract: | Three new flavonoids, 6,7-dimethoxy-4′-hydroxy-8-formylflavon (1), 8-formyl-4′,6,7-trimethoxyflavon (2), 4′,7-dihydroxy-8-formyl-6-methoxyflavon (3), together with fifteen known flavonoids (4–18) were isolated from the leaves of oriental tobacco (a variety of Nicotiana tabacum L). Their structures were determined by means of HRESIMS, extensive 1D and 2D NMR spectroscopic studies and chemical evidences. The cytotoxicity against five human tumor (NB4, A549, SHSY5Y, PC3, and MCF7) cell lines of compounds 1–3 were also evaluated. The results showed that compounds 1 and 3 showed high cytotoxicity against PC3 and A549 cell lines with IC50 values of 2.6 and 1.6 μM, respectively. |
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