The fusarin analog NG-391 impairs nucleic acid formation in K-562 leukemia cells |
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| Authors: | Markus Bohnert Hans-Martin Dahse Donna M. Gibson Stuart B. Krasnoff Dirk Hoffmeister |
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| Affiliation: | 1. Friedrich-Schiller-Universität Jena, Department of Pharmaceutical Biology at the Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany;2. Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany;3. United States Department of Agriculture-Agricultural Research Service (USDA-ARS), Biological Integrated Pest Management Unit, RW Holley Center for Agriculture and Health, 538 Tower Road, Ithaca, NY 14853, USA |
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| Abstract: | The clavicipitaceous fungus Metarhizium robertsii produces the fusarin-like mycotoxin NG-391. We report on the biological effects of NG-391 on K-562 human cancer cells, obtained with radionuclide incorporation assays, along with nucleosome release and caspase assays, respectively. Our data suggests that NG-391 does not induce caspase-dependent apoptosis, but interferes with nucleic acid biosynthesis in K-562 human cancer cells, while translation remains unaffected. |
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