A new biologically active triterpenoid saponin from the aerial parts of Neanotis wightiana |
| |
Authors: | Niranjan Das Partha Sarathi Ghosh Manash Chandra Das Biswanath Dinda |
| |
Affiliation: | 1. Department of Chemistry, Netaji Subhas Mahavidyalaya, Udaipur 799 114, Gomati Tripura, India;2. Department of Chemistry, Tripura University, Suryamaninagar 799 022, West Tripura, India;3. Department of Medical Lab Technology, Women''s Polytechnic, Hapania 799 014, West Tripura, India |
| |
Abstract: | Phytochemical investigation of the aerial parts of Neanotis wightiana for the first time has led to the isolation of one new triterpenoid saponin, neanoside A (1), along with seven known compounds, oleanolic acid (2), ursolic acid (3), β-sitosterol (4) and its glucoside (5), stigmasterol (6) and its glucoside (7) and hexacosanoic acid (8). The structures of these compounds were elucidated by means of spectroscopic (NMR, MS and other) and chemical techniques as well as comparison with literature data. The structure of 1 was elucidated as 3-O-α-l-rhamnopyranosyl-(1 → 2)-β-d-xylopyranosyl (1 → 3)-β-d-glucopyranosyl bayogenin. The in vitro biochemical analysis of compound 1 against the activity of human serum liposomal enzymes, SGOT (serum glutamate oxaloacetate transaminase), SGPT (serum glutamate pyruvate transaminase) and ALP (alkaline phosphatase) and glycerol kinase showed significant reduction of their activity. |
| |
Keywords: | Neanotis wightiana Rubiaceae Triterpenoids |
本文献已被 ScienceDirect 等数据库收录! |
|